15.25 AMA PRA Category 1 Credits*
Essential Knowledge in the Clinical Use of Peptides for Age Management Medicine
The use of Peptides and Peptide Therapies has experienced exponential growth over the past few years. Their uses range from impacting hormonal change, to antibiotic properties, to treatments for conditions of aging such as cancer, cardiovascular health, memory & brain health and sexual function. AMMG in conjunction with the Clinical Peptide Society have an educational mandate is to fill knowledge gaps for physicians and healthcare professionals. This course is a focused track on essential knowledge in the clinical use of peptides for Age Management and will include a through discussion, a compare and contrast of those Peptides which are approved in the United States and can be compounded and those which are not. Course will also include a final examination for Certification.
In conjunction with the Clinical Peptide Society
3-Part Process to complete the Peptide Certification Course of Study:
- Home Study Online - 8.25 hrs: Clinical Use of Peptides and Peptides Therapy - Full Course
- Complete at your own pace. Completion of the online course is a prerequisite to certification.
- Course Access: After registering you will receive an email with your username and password to access the online course. NOTE: It can take up to 3 days to process.
- Review Questions: You will receive an additional email with review questions to be answered after viewing each video. These question must be submitted to AMMG prior to the live training.
- Live Training at AMMG Conference - 7 hrs: Essential Knowledge in the Clinical Use of Peptides for Age Management Medicine
- This full day live course will be held November 8 at the AMMG Conference in Dallas, Texas.
- This full day live course will be held November 8 at the AMMG Conference in Dallas, Texas.
- Comprehensive Final Exam: The final exam will be given Immediately following the last lecture at the live course which will be held November 8 at the AMMG Conference in Dallas, Texas.
COMPLIANCE DISCLOSURE: AMMG has made every effort to have all lectures and statements made regarding Peptides comply with all FDA and State and Local laws. There are some Peptides which the FDA has not approved for compounding. This is a new and potentially changing area of medicine and we encourage you to frequently check for new policies, laws and rules which may apply to your practice and to strictly adhere to all laws which apply.
8.25 AMA PRA Category 1 Credits
Part 1: online Course Content
You can begin the online study immediately and complete at your own pace. Completion of the online course is a prerequisite to certification.
The Clinical Use of Peptides and Peptide Therapies – Full Course course is included in the Certification program registration cost. After registering you will receive an email from AMMG with your login access to this online portion of the Peptides Certification. NOTE: It can take up to 3 days to process.
The world of peptides therapy is a growing field in medicine ranging from improving skin care, growth hormone, to one’s immune system, to name a few. On PubMed there are over 2.5 million articles on peptides. It is estimated that humans have over 250,000 peptides and we only understand a fraction of them. Peptides are chains of amino acids linked together by a polypeptide bond. The formation of a polypeptide bond by a dehydration synthesis will be reviewed. The difference of a peptide versus a protein will be delineated. In addition the mechanism of action on how peptides work will be reviewed.
Peptides—you have heard of them, but how and when do you use them? These simple short chains of amino acids regulate almost every known system and process in the body to include hormone production. In this lecture you will discover some of the uses of BPC-157. Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound that was discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendon to bone healing and healing of damaged ligaments. Additionally, BPC 157 seems to protect organs and to heal and prevent ulcers of the stomach. This peptide has also been demonstrated to reduce pain in areas of damaged tissue, mitigating the need for narcotic type medications. Individuals who are suffering from muscle sprains, tears, and damage can benefit from treatment with this unique peptide.
Brain health is an important consideration for health and well-being. To date, drugs targeting a single pathological pathway have failed to show clinical efficacy for concussions, TBI, memory loss and dementia. Nootropic peptides are pleiotropic agents with effects on multiple mechanisms of brain injury that are an effective option to improve brain recovery and clinical outcome for restoring brain health.
Growth hormone is an essential hormone in lowering body fat, improving on lipids, keeping muscles healthy and improving on bone density. Adult growth hormone deficiency symptoms will be reviewed and the association of higher mortality with growth hormone deficiency. Unfortunately the treatment with recombinant human growth hormone is not covered under most insurance plans and it is also cost prohibitive for most people. There is an alternative to the expensive recombinant human growth hormone mostly commonly used for boosting IGF-1 and has the advantage of inducing all five of the hGH isoforms rather just the one that is found in the synthetic form. CJC-1295, Ipamorelin, GHRP-6, Teslomorelin and others are peptides that have been shown to help improve IGF-1 levels.
It is estimated that there are about 250,000 peptides in the human body. We only understand a fraction of all the peptides. This talk will cover a wide range of issues. Delta Sleep Induced Peptide can help with restoring sleep. Epithalon is a peptide discovered by a famous Russia scientist Dr Khavinson. He has published extensively since the 1970’s and has published the longest human study on epithalon improving longevity and also increasing telomere lengths. A new drug is being developed to help with sexual dysfunction. This drug is the peptide Bremelanotide PT 141. The love peptide hormone kisspeptin will be reviewed. In addition Semax will be discussed to help with memory.
Recent advances in peptide biology have found multiple peptides capable of exerting therapeutic benefits in the treatment of cancer. This lecture will discuss peptide classes, mechanisms of action and proposed protocols for incorporating peptide therapy in the treatment of cancer patients.
Thymosins have been recognized as key peptides that help to regulate our immune system. As biological response modifiers, they are now being used in the treatment of disease with significant results and promise. These “new medicines”, based on discoveries in the areas of host immunity and regenerative medicine, have provided clinicians with additional treatment options in the treatment of autoimmune and infectious diseases. The thymosins can synergize with supplements and conventional therapies, increasing the effectiveness of the treatment protocol.
Immune dysregulation, a universal characteristic of autoimmune diseases, can be targeted through the use of specific peptides. This lecture will present the rationale for utilizing peptide therapy in the management of autoimmune diseases. T-cell modulation, OGF axis and other mechanisms of action will be highlighted. Cases and protocols will be discussed.
Murderers, Rapists, and Terrorists have rights, but physicians do not! You are guilty and you can not prove your innocence. The facts are, a doctor can have a license sanctioned, suspended, revoked, limited, be bankrupted, disgraced, and made unemployable, based on an anonymous complaint that might have come from a disgruntled employee, a jealous competitor, an insurance company that doesn’t want to pay a bill, or a drug addict who wants a lighter sentence. And you have no right to know who the accuser is or even what you are being accused of committing. Board employees function as investigator, prosecutor, judge, jury, and executioner. The politically appointed members of the board almost always rubber-stamp what the board staff wants. The staff generally controls the flow of information to board members and accused doctors. The doctor has no right to cross-examine accusers, to ask that conflicted or biased staff be recused, or to challenge the evidence against him or her, which he might not even have seen. In short, modern day medical boards are the equivalent of medieval Consiglio dei Dieci only falling short by not being able to send you to the Judas Cradle. So how do you protect yourself? In this lecture we will explore the many avenues you can approach to provide as much protection as you can for your hard earned medical license.
There are about 300 theories of aging ranging from the neuroendocrine, free radical, cell membrane, Hayflick limit, mitochondria, cross link, autoimmune, glycation, and others. Most scientists have narrowed the specifics of what affects how we age down to 2 theories. The first group states that aging is natural and programmed into the body, while the second group of aging theories says that aging is a result of damage which is accumulated over time. Working on hormonal optimization, removing toxins, improving on nutrition, reducing stress, and increasing physical activity helps in slowing the aging process. In addition, using 3 peptides can also help in slowing the aging process. The peptides Epithalon, Thymosin Alpha 1 and BPC-157 help improve the telomeres, reduce inflammation, improve on the production of type 1 collagen and also improve the immune system. Pertinent medical studies on the 3 peptides will be reviewed in this talk.
Peptides are natural bio-regulators with diverse effects in the body and are emerging as a novel therapy for bio-regulation. Peptides function in cell-signaling and exert regulatory actions on neuro-endo-immune function. Presently, peptides are used in orthopedics, and neuro-endo-immune conditions for the treatment of injury, pain syndromes, IBD, brain health and immune system dysregulation.
Edwin N. Lee, M.D., FACE
Kathy O’Neil-Smith, M.D., FAARM
Rob Kominiarek, D.O., FACOFP
Luis Martínez, M.D., MPH
The world of peptides therapy is a growing field in medicine ranging from improving skin care, to growth hormone, to one’s immune system, to name a few. On Pub Med there are over 2.5 million articles on peptides. It is estimated that humans have over 250,000 peptides and we only understand a fraction of them. Peptides are chains of amino acids linked together by a polypeptide bond. The formation of a polypeptide bond by a dehydration synthesis will be reviewed. The difference between a peptide and a protein will be delineated. In addition the mechanism of action on how peptides work will be reviewed. The history of peptides will be covered and also knowing which hormones are peptides will be reviewed. Peptides have pleotropic effects and during the conference this subject will be addressed.
Growth hormone is an essential hormone in lowering body fat, improving on lipids, keeping muscles healthy and improving on bone density. Adult growth hormone deficiency symptoms will be reviewed and the association of higher mortality with growth hormone deficiency. Unfortunately the treatment with recombinant human growth hormone is not covered under most insurance plans, and it is cost prohibitive for most people. There is an alternative to the expensive recombinant human growth hormone most commonly used for boosting IGF-1 and it has the advantage of inducing all five of the hGH isoforms rather just the one that is found in the synthetic form. CJC-1295, Ipamorelin, GHRP-6, Teslomorelin and others are peptides that have been shown to help improve IGF-1 levels.
The thymosins are a group of peptides originally associated with the thymus gland. They possess pleiotropic effects on in humans. Thymosin Alpha 1 has long been studied for its immune enhancing properties, with regulatory approvals in the management of certain viral diseases and cancers. On the other hand, Thymosin Beta 4 has been shown to improve regeneration in multiple tissues.
BPC-157 was discovered in the 1990s in gastric juice. However I give credit to Dr. Pavlov in Russia in the early 1900s since he was manufacturing gastric juice from dogs to help heal many alignments. At that time they did not have the technology to detect BPC-157. BPC-157 has been studied extensively in animals and has been shown to improve on healing the body. Studies with BPC-157 have been shown to heal a severed tendon, nerve, and also ulcers. Although there are no human clinical trials the body builders has been using BPC-157 experimentally to repair their torn muscles, tendons and ligaments. In this lecture the published studies of BPC-157 ranging from colitis, inflammatory bowel disease, systemic steroid impaired muscle healing, bone defect, periodontitis, and others will be reviewed. Although the FDA has not approved this peptide, BPC-157 has been used worldwide.
Millions of Americans suffer from autoimmune diseases. Immune dysregulation, a universal characteristic of autoimmune diseases, can be targeted through the use of specific peptides. This lecture will present the rationale for utilizing peptide therapy in the management of autoimmune diseases. T cell modulation, cell predominant shifts, OGF axis and other mechanisms of action will be highlighted. VIP, thymosins and other peptides will be covered. Cases and protocols will be discussed.
Advances in peptide biology have shed light on multiple pathways which can be targeted for therapeutic interventions with the use of peptides. These can be incorporated as part of a comprehensive cancer management approach. The lecture will discuss peptide classes, mechanisms of action and proposed protocols for incorporating peptide therapy in the treatment of cancer patients. Peptides including Met-Enkephalin, PNC 27, P18 among others will be discussed. Oncostatic and oncolytic characteristics will be reviewed.
An estimated 6 million Americans have Alzheimer’s disease, 10 million people worldwide with Parkinson’s, 3 million Americans suffer from traumatic brain injury (TBI), and approximately 800,000 will suffer from a stroke each year. There are peptides that have been shown to have neuroregenerative properties that have clinical studies in strokes, traumatic brain injury, Parkinson’s and in Alzheimer’s disease. There are many mechanisms that are involved with neurodegenerative diseases to traumatic brain injury. Inflammation in the brain, excessive oxidative stress, mitochondrial impairment, and excitotoxicity are common theme that can lead to damage or death of the neuron or myelin. Peptides have been shown to reduce inflammation, reduce oxidative stress, increase the production of brain derived neurotrophic factor and also increase the production of neurons. The peptides of Thymosin Beta 4, BPC-157, Cerebrolyin, Dihexa and Semax will be covered.
Alpha melatonin stimulating hormone analogues, including PT 141 and Melanotan, can act on multiple melanocortin receptors. As such, they have been studied and are currently being used for multiple indications, including increasing libido, altering skin pigmentation and modulating food intake. Epitalon is a pineal peptide, originally studied in Russia. It has been shown to activate telomerase, restore melatonin secretion and reduce mortality in users. This lecture will review both pineal and pituitary physiology as they relate to these peptides. Melanocortin receptors and neuropetides will be discussed.
Edwin N. Lee, M.D., FACE
Luis Martínez, M.D., MPH
Part 3: Comprehensive Final Exam
The final exam will be given Immediately following the last lecture at the live course which will be held April 23 at the AMMG Miami, Florida Conference.