Nutrigenomics and Epigenetics: How Environmental Factors and Nutrient Deficiencies Affect our Genetic Expression

Derrick DeSilva, Jr., M.D.

Teaching Faculty, JFK Medical Center, Edison, NJ; Co-Chair, Department of Complimentary Medicine and Senior Attending Staff, Raritan Bay Medical Center, Perth Amboy, NJ

Reverse aging is no longer science fiction. Leading edge science and technological advancements have provided unprecedented discoveries in the field of aging and age rejuvenation. Recently, nine hallmarks of aging were identified genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell loss, and altered intercellular communication. These discoveries provide us with an opportunity to create interventions which mitigate the ravages of aging and importantly, provide the ability to rejuvenate the aging system to a place of youthful longevity. In order to achieve optimal age rejuvenation outcomes, a synergistic, stepwise approach is required.