Advanced Course: Essential Knowledge in Peptides for Age Management Medicine

8.25 CME Hours + 7.0 Additional Lecture Hours – $1250.00

The use of Peptides and Peptide Therapies has experienced exponential growth over the past few years. Their uses range from impacting hormonal change, to antibiotic properties, to treatments for conditions of aging such as cancer, cardiovascular health, memory & brain health and sexual function. AMMG in conjunction with the Clinical Peptide Society have an educational mandate is to fill the scientific and medical knowledge gaps for physicians and healthcare professionals.

This course is a focused track on essential knowledge in the clinical use of peptides for Age Management and will include discussions regarding those Peptides which are approved in the United States and can be compounded and those which are not. At the completion of parts 1-3 of this course, 15.25 hours of educational content and successfully passing the examination applicants will receive a Certificate of Completion for their study in Peptides.

In conjunction with the Clinical Peptide Society

*COMPLIANCE DISCLOSURE: AMMG has made every effort to have all lectures and statements made regarding Peptides comply with all FDA and State and Local laws. There are some Peptides which the FDA has not approved for compounding. This is a new and potentially changing area of medicine and we encourage you to frequently check for new policies, laws and rules which may apply to your practice and to strictly adhere to all laws which apply.

Status of Peptides

Curriculum: PART 1

The world of peptides therapy is a growing field in medicine ranging from improving skin care, growth hormone, to one’s immune system, to name a few. On PubMed there are over 2.5 million articles on peptides. It is estimated that humans have over 250,000 peptides and we only understand a fraction of them. Peptides are chains of amino acids linked together by a polypeptide bond. The formation of a polypeptide bond by a dehydration synthesis will be reviewed. The difference of a peptide versus a protein will be delineated. In addition the mechanism of action on how peptides work will be reviewed.

Edwin N. Lee, M.D., FACE

Peptides—you have heard of them, but how and when do you use them? These simple short chains of amino acids regulate almost every known system and process in the body to include hormone production. In this lecture you will discover some of the uses of BPC-157. Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound that was discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendon to bone healing and healing of damaged ligaments. Additionally, BPC 157 seems to protect organs and to heal and prevent ulcers of the stomach. This peptide has also been demonstrated to reduce pain in areas of damaged tissue, mitigating the need for narcotic type medications. Individuals who are suffering from muscle sprains, tears, and damage can benefit from treatment with this unique peptide.

Rob Kominiarek, D.O., FACOFP

Brain health is an important consideration for health and well-being. To date, drugs targeting a single pathological pathway have failed to show clinical efficacy for concussions, TBI, memory loss and dementia. Nootropic peptides are pleiotropic agents with effects on multiple mechanisms of brain injury that are an effective option to improve brain recovery and clinical outcome for restoring brain health.

Kathy O’Neil-Smith, M.D., FAARM

Growth hormone is an essential hormone in lowering body fat, improving on lipids, keeping muscles healthy and improving on bone density. Adult growth hormone deficiency symptoms will be reviewed and the association of higher mortality with growth hormone deficiency. Unfortunately the treatment with recombinant human growth hormone is not covered under most insurance plans and it is also cost prohibitive for most people. There is an alternative to the expensive recombinant human growth hormone mostly commonly used for boosting IGF-1 and has the advantage of inducing all five of the hGH isoforms rather just the one that is found in the synthetic form. CJC-1295, Ipamorelin, GHRP-6, Teslomorelin and others are peptides that have been shown to help improve IGF-1 levels.

Edwin N. Lee, M.D., FACE

It is estimated that there are about 250,000 peptides in the human body. We only understand a fraction of all the peptides. This talk will cover a wide range of issues. Delta Sleep Induced Peptide can help with restoring sleep. Epithalon is a peptide discovered by a famous Russia scientist Dr Khavinson. He has published extensively since the 1970’s and has published the longest human study on epithalon improving longevity and also increasing telomere lengths. A new drug is being developed to help with sexual dysfunction. This drug is the peptide Bremelanotide PT 141. The love peptide hormone kisspeptin will be reviewed. In addition Semax will be discussed to help with memory.

Edwin N. Lee, M.D., FACE

Recent advances in peptide biology have found multiple peptides capable of exerting therapeutic benefits in the treatment of cancer. This lecture will discuss peptide classes, mechanisms of action and proposed protocols for incorporating peptide therapy in the treatment of cancer patients.

Luis Martínez, M.D., MPH

Thymosins have been recognized as key peptides that help to regulate our immune system. As biological response modifiers, they are now being used in the treatment of disease with significant results and promise. These “new medicines”, based on discoveries in the areas of host immunity and regenerative medicine, have provided clinicians with additional treatment options in the treatment of autoimmune and infectious diseases. The thymosins can synergize with supplements and conventional therapies, increasing the effectiveness of the treatment protocol.

Kathy O’Neil-Smith, M.D., FAARM

Immune dysregulation, a universal characteristic of autoimmune diseases, can be targeted through the use of specific peptides. This lecture will present the rationale for utilizing peptide therapy in the management of autoimmune diseases. T-cell modulation, OGF axis and other mechanisms of action will be highlighted. Cases and protocols will be discussed.

Luis Martínez, M.D., MPH

Murderers, Rapists, and Terrorists have rights, but physicians do not! You are guilty and you can not prove your innocence. The facts are, a doctor can have a license sanctioned, suspended, revoked, limited, be bankrupted, disgraced, and made unemployable, based on an anonymous complaint that might have come from a disgruntled employee, a jealous competitor, an insurance company that doesn’t want to pay a bill, or a drug addict who wants a lighter sentence. And you have no right to know who the accuser is or even what you are being accused of committing. Board employees function as investigator, prosecutor, judge, jury, and executioner. The politically appointed members of the board almost always rubber-stamp what the board staff wants. The staff generally controls the flow of information to board members and accused doctors. The doctor has no right to cross-examine accusers, to ask that conflicted or biased staff be recused, or to challenge the evidence against him or her, which he might not even have seen. In short, modern day medical boards are the equivalent of medieval Consiglio dei Dieci only falling short by not being able to send you to the Judas Cradle. So how do you protect yourself? In this lecture we will explore the many avenues you can approach to provide as much protection as you can for your hard earned medical license.

Rob Kominiarek, D.O., FACOFP

There are about 300 theories of aging ranging from the neuroendocrine, free radical, cell membrane, Hayflick limit, mitochondria, cross link, autoimmune, glycation, and others. Most scientists have narrowed the specifics of what affects how we age down to 2 theories. The first group states that aging is natural and programmed into the body, while the second group of aging theories says that aging is a result of damage which is accumulated over time. Working on hormonal optimization, removing toxins, improving on nutrition, reducing stress, and increasing physical activity helps in slowing the aging process. In addition, using 3 peptides can also help in slowing the aging process. The peptides Epithalon, Thymosin Alpha 1 and BPC-157 help improve the telomeres, reduce inflammation, improve on the production of type 1 collagen and also improve the immune system. Pertinent medical studies on the 3 peptides will be reviewed in this talk.

Edwin N. Lee, M.D., FACE

Peptides are natural bio-regulators with diverse effects in the body and are emerging as a novel therapy for bio-regulation. Peptides function in cell-signaling and exert regulatory actions on neuro-endo-immune function. Presently, peptides are used in orthopedics, and neuro-endo-immune conditions for the treatment of injury, pain syndromes, IBD, brain health and immune system dysregulation.

Kathy O’Neil-Smith, M.D., FAARM

There are about 300 theories of aging ranging from the neuroendocrine, free radical, cell membrane, Hayflick limit, mitochondria, cross link, autoimmune, glycation, and others. Most scientists have narrowed the specifics of what affects how we age down to 2 theories. The first group states that aging is natural and programmed into the body, while the second group of aging theories says that aging is a result of damage which is accumulated over time. Working on hormonal optimization, removing toxins, improving on nutrition, reducing stress, and increasing physical activity helps in slowing the aging process. In addition, using 3 peptides can also help in slowing the aging process. The peptides Epithalon, Thymosin Alpha 1 and BPC-157 help improve the telomeres, reduce inflammation, improve on the production of type 1 collagen and also improve the immune system. Pertinent medical studies on the 3 peptides will be reviewed in this talk.

Edwin N. Lee, M.D., FACE

Edwin N. Lee, M.D., FACE
Kathy O’Neil-Smith, M.D., FAARM
Rob Kominiarek, D.O., FACOFP
Luis Martínez, M.D., MPH

Curriculum: PART 2

The world of peptides therapy is a growing field in medicine ranging from improving skin care, to growth hormone, to one’s immune system, to name a few. On Pub Med there are over 2.5 million articles on peptides. It is estimated that humans have over 250,000 peptides and we only understand a fraction of them. Peptides are chains of amino acids linked together by a polypeptide bond. The formation of a polypeptide bond by a dehydration synthesis will be reviewed. The difference between a peptide and a protein will be delineated. In addition the mechanism of action on how peptides work will be reviewed. The history of peptides will be covered and also knowing which hormones are peptides will be reviewed. Peptides have pleotropic effects and during the conference this subject will be addressed.

Edwin N. Lee, M.D., FACE

Growth hormone is an essential hormone in lowering body fat, improving on lipids, keeping muscles healthy and improving on bone density. Adult growth hormone deficiency symptoms will be reviewed and the association of higher mortality with growth hormone deficiency. Unfortunately the treatment with recombinant human growth hormone is not covered under most insurance plans, and it is cost prohibitive for most people. There is an alternative to the expensive recombinant human growth hormone most commonly used for boosting IGF-1 and it has the advantage of inducing all five of the hGH isoforms rather just the one that is found in the synthetic form. CJC-1295, Ipamorelin, GHRP-6, Teslomorelin and others are peptides that have been shown to help improve IGF-1 levels.

Edwin N. Lee, M.D., FACE

Millions of Americans suffer from autoimmune diseases. Immune dysregulation, a universal characteristic of autoimmune diseases, can be targeted through the use of specific peptides. This lecture will present the rationale for utilizing peptide therapy in the management of autoimmune diseases. T cell modulation, cell predominant shifts, OGF axis and other mechanisms of action will be highlighted. VIP, thymosins and other peptides will be covered. Cases and protocols will be discussed.

Luis Martínez, M.D., MPH

BPC-157 was discovered in the 1990s in gastric juice. However I give credit to Dr. Pavlov in Russia in the early 1900s since he was manufacturing gastric juice from dogs to help heal many alignments. At that time they did not have the technology to detect BPC-157. BPC-157 has been studied extensively in animals and has been shown to improve on healing the body. Studies with BPC-157 have been shown to heal a severed tendon, nerve, and also ulcers. Although there are no human clinical trials the body builders has been using BPC-157 experimentally to repair their torn muscles, tendons and ligaments. In this lecture the published studies of BPC-157 ranging from colitis, inflammatory bowel disease, systemic steroid impaired muscle healing, bone defect, periodontitis, and others will be reviewed. Although the FDA has not approved this peptide, BPC-157 has been used worldwide.

Edwin N. Lee, M.D., FACE

Millions of Americans suffer from autoimmune diseases. Immune dysregulation, a universal characteristic of autoimmune diseases, can be targeted through the use of specific peptides. This lecture will present the rationale for utilizing peptide therapy in the management of autoimmune diseases. T cell modulation, cell predominant shifts, OGF axis and other mechanisms of action will be highlighted. VIP, thymosins and other peptides will be covered. Cases and protocols will be discussed.

Luis Martínez, M.D., MPH

Advances in peptide biology have shed light on multiple pathways which can be targeted for therapeutic interventions with the use of peptides. These can be incorporated as part of a comprehensive cancer management approach. The lecture will discuss peptide classes, mechanisms of action and proposed protocols for incorporating peptide therapy in the treatment of cancer patients. Peptides including Met-Enkephalin, PNC 27, P18 among others will be discussed. Oncostatic and oncolytic characteristics will be reviewed.

Luis Martínez, M.D., MPH

An estimated 6 million Americans have Alzheimer’s disease, 10 million people worldwide with Parkinson’s, 3 million Americans suffer from traumatic brain injury (TBI), and approximately 800,000 will suffer from a stroke each year. There are peptides that have been shown to have neuroregenerative properties that have clinical studies in strokes, traumatic brain injury, Parkinson’s and in Alzheimer’s disease. There are many mechanisms that are involved with neurodegenerative diseases to traumatic brain injury. Inflammation in the brain, excessive oxidative stress, mitochondrial impairment, and excitotoxicity are common theme that can lead to damage or death of the neuron or myelin. Peptides have been shown to reduce inflammation, reduce oxidative stress, increase the production of brain derived neurotrophic factor and also increase the production of neurons. The peptides of Thymosin Beta 4, BPC-157, Cerebrolyin, Dihexa and Semax will be covered.

Edwin N. Lee, M.D., FACE

Alpha melatonin stimulating hormone analogues, including PT 141 and Melanotan, can act on multiple melanocortin receptors. As such, they have been studied and are currently being used for multiple indications, including increasing libido, altering skin pigmentation and modulating food intake. Epitalon is a pineal peptide, originally studied in Russia. It has been shown to activate telomerase, restore melatonin secretion and reduce mortality in users. This lecture will review both pineal and pituitary physiology as they relate to these peptides. Melanocortin receptors and neuropetides will be discussed.

Edwin N. Lee, M.D., FACE

FACULTY

  • Assistant Professor of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL
  • Founder, Institute for Hormonal Balance, Orlando, FL
  • Member, AMMG Conference Planning Committee
  • Co-Founder, Clinical Peptide Society

Kominiarek, Rob A. - D.O.Rob Kominiarek, D.O., FACOFP is a board-certified Fellow of the American College of Osteopathic Family Physicians and a Fellows Crest Award Winner in Family Medicine with advanced training in Age Management Medicine and Hormone Optimization. He is president and medical director of ReNue Health®. Dr. Rob is a graduate of the Nova-Southeastern University College of Osteopathic Medicine in Fort Lauderdale, FL. He completed his residency training at Ohio University, Grandview Hospital and Medical Center in Dayton, OH and is an Assistant Clinical Professor at Ohio University. An Amazon bestselling author and Executive Producer of a weekly health segment, ͞Dr. Rob In the House͟ on NBC2 in Dayton, OH, Dr. Rob is a medical advisor and director to emergency medical services, police departments and radio and television shows across the country. He is a veteran of the United States Army with a passion directed towards overall health of the mind and body through proper nutritional habits, regular exercise, appropriate supplementation, and the intelligent optimization of hormones when clinically indicated. An avid athlete who enjoys cycling, swimming, triathlons, soccer, tennis, soaring, skiing Utah, Italian motorcycles, and automobile racing, Dr. Rob is a dedicated father who believes in practicing what he preaches, and as such lives a lifestyle dedicated towards healthy living and regular exercise.

  • Assistant Professor of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL
  • Founder, Institute for Hormonal Balance, Orlando, FL
  • Member, AMMG Conference Planning Committee
  • Co-Founder, Clinical Peptide Society

Edwin N. Lee, M.D., FACE | AMMG Conference Faculty  Dr. Edwin Lee is an endocrinologist, author and international speaker. Dr. Lee founded the Institute for Hormonal Balance, Orlando, FL in 2008, is board certified in Internal Medicine, Endocrinology, Diabetes and Metabolism, and has completed special training in Regenerative and Functional Medicine. Currently, he is the assistant professor of Internal Medicine at the University of Central Florida College of Medicine. In addition to writing his award winning books, “Your Amazing Heart,” “Your Awesome Brain,” “Feel Good Look Younger: Reversing Tiredness Through Hormonal Balance,” and “Your Best Investment: Secrets to a Healthy Body and Mind,” Dr. Lee has published many articles on internal medicine and endocrinology. He was also an author in the fourth edition of Textbook of Critical Care. His passion is healthy living and he practices what he preaches. He enjoys participating in open water swimming, cycling, hiking and Aquabike competition. Dr. Edwin Lee resides in Orlando, FL with his wife and 2 teenage boys.

CME Disclosure: No Relevant Financial Interest in any Products or Services to be discussed

  • Assistant Professor of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL
  • Founder, Institute for Hormonal Balance, Orlando, FL
  • Member, AMMG Conference Planning Committee
  • Co-Founder, Clinical Peptide Society

Martinez, Luis - M.D., MPH

Dr. Luis Martínez is a Regenerative Medicine and Cell Therapy specialist, clinical researcher and biomedical consultant. He earned his medical degree at The Ponce School of Medicine and completed his residency training at the prestigious University of Pennsylvania. He also completed an Advanced Training Course in Stem Cells in Cancer at the Ponce Health Sciences University/ Magee Research Institute consortium. He is board certified in Clinical Lipidology. Dr. Martinez holds a Masters of Public Health with a concentration in Epidemiology and is fellowship trained in Biosecurity. He is the president of Xanogene Clinic, which specialized in Regenerative and Age Management Medicine. He also founded and presides over Regenera Global, a multinational corporation specializing in biotech product development, research, and clinical consulting.

Dr. Martinez has advised and helped set up various clinics and laboratories in Latin America within the Regenerative Medicine space. He also serves on the advisory board for various Biotech companies and professional societies. He is actively involved in educating and training physicians in multiple aspects of Regenerative and Age Management Medicine.

CME Disclosure: No Relevant Financial Interest in any Products or Services to be discussed

  • Assistant Professor of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL
  • Founder, Institute for Hormonal Balance, Orlando, FL
  • Member, AMMG Conference Planning Committee
  • Co-Founder, Clinical Peptide Society

Kathy O’Neil-Smith, M.D., FAARMDr. Kathleen O’Neil-Smith is a magna cum laude graduate of Boston University Medical School. She completed an internship in pathology at Massachusetts General Hospital followed by an internship and residency in internal medicine at the Brigham and Women’s Hospital in Boston. In 2008, she completed a two-year fellowship in functional medicine through the American Academy of Anti-Aging and Regenerative Medicine, as well as a Stem Cell Fellowship at A4M and a TBI certification at AMMG. She has been on the faculty at Tufts University School of Medicine and Boston University School of Medicine. She competed as a member and later coach, of the United States Women’s National Rowing Team and continues to race competitively every year at The Head of The Charles Regatta in Boston. Dr. O’Neil-Smith is Medical Director at TB12 Sports Center in Foxboro, MA. She is a compassionate, innovative and conscientious physician, committed to excellence, and dedicated to offer the most cutting edge safe therapies to her patients.

Instructions for Completing your Certificate

Completing all steps is a requirement in order to qualify to receive your Certificate.

  • Review the Learner Notification
  • Watch ALL videos in Part 1
  • Complete the Course Evaluation at the end of Part 1 in it’s entirety.
  • At the completion of the Course Evaluation you will be taken to a screen where you can immediately print a copy of your CME Certification for Part 1.
    • IMPORTANT: Do not exit until you have completed both the Course Evaluation and the CME Certificate
    • A copy will also be emailed to the address you used to sign up. If you don’t receive it immediately check your SPAM folder.
  • Watch ALL videos in Part 2
  • After completing the Part 2 videos “Go to Final Exam” and complete the entire Final Exam
  • You must receive a score 75% or higher in order to be eligible for an Advanced Course Certificate
  • If your score is not sufficient to earn the Advanced Course Certificate you may retake to test.
  • AMMG will mail your Advanced Course Certificate to you.
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