Clinical Use of Naltrexone Therapy in Age Management Medicine

4 Lectures – $195.00

Courses are Enduring Materials from a Clinical Applications for Age Management Medicine Conference

This series focuses on Naltrexone Therapy in Age Management Medicine— it’s principles of use, low dose & subcutaneous therapies for management and relief of addiction and weight loss inhibits inflammatory pathways. Current practicing clinicians will especially benefit from this new and cutting-edge information.


Naltrexone, an FDA-approved drug indicated for relief of addiction to opiate drugs, such as heroin or morphine, inhibits inflammatory pathways that involve Toll-Like Receptors. In 1985, spurred by the AIDS crisis, and with little else to treat the horrendous infections developing in their patients, several enterprising physicians surmised that naltrexone’s anti-inflammatory properties could be harnessed at a more local level diluting its potency, thereby shortening its duration of action. The result?  A powerful new anti-inflammatory agent was born. Diluted at first to 10%, then eventually as low as 2% of its original potency, “low dose” naltrexone proved to be a boon to chronic fatigue, multiple sclerosis, CFS/ME, autoimmune thyroid diseases, and various cancers. Seasoned clinicians might be skeptical about how a single entity could exact benefit from such a wide range of pathologies. Still, a careful study of LDN’s properties reveal it is effective against dozens of inflammatory intermediaries such as interleukin (IL)-1β, IL-1Ra, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-15, IL-17A, IL-27, interferon (IFN)-α, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, and granulocyte-colony stimulating factor (G-CSF). This lecture will explore the history, indications, mechanism of action, dose schedules, side effects, and evidence-based studies using low-dose naltrexone. The audience participant will have a firm grasp of the appropriate uses of low-dose naltrexone and its contraindications and idiosyncrasies. We will briefly touch on ultra-low-dose naltrexone for use in specialty situations. Lastly, we will explore a case study to highlight LDN’s usefulness as a therapeutic modality.

William Clearfield, D.O., FAAMA, DABMA, FAARFM
Medical Director, Clearfield Family Medicine, Reno, NV, Executive Director, American Osteopathic Society of Rheumatic Diseases

Naltrexone is a competitive antagonist of the opioid receptors which has been used for decades in the management of substance abuse disorders. Interestingly, opioid receptors can affect multiple biological aspects including immune function and inflammation. This lecture will review the history and use of Naltrexone and the biological mechanisms related the opioid receptors. Immune modulation and anti-inflammatory effects of transient receptor blockade will be discussed. The effects of the different Naltrexone dosing regimens and their biological effects will be reviewed. Finally, opioid receptor modulation and its implications will be presented as a strategy to incorporate in Age Management Medicine.

Luis Martínez, M.D., MPH
President, XanoGene Clinic, San Juan, Puerto Rico, President, Regenera Global, Ponce, Puerto Rico

Naltrexone is FDA approved either as a stand-alone therapy or as combination therapy for the management of addictions and weight loss. One of the challenges with naltrexone therapies as it relates to these conditions is compliance. Subcutaneous Naltrexone Therapy (SNT) is an option for many patients who are candidates for therapy. This lecture will review the history of naltrexone implants and the evidence for their use. We will also detail how the actual procedure is performed and dosing will be discussed. Attendees will learn the fundamentals of incorporating Subcutaneous Naltrexone Therapy in their practices.

Subcutaneous Naltrexone Therapy (SNT) For the Management of Addictions and for Weight Loss

Luis Martínez, M.D., MPH
President, XanoGene Clinic, San Juan, Puerto Rico, President, Regenera Global, Ponce, Puerto Rico

When performing Subcutaneous Naltrexone Therapy, it is important to understand dosing, possible side effects and proper follow up. This lecture will present the protocols for SNT and an interactive case discussion will ensue. Clinical pearls and pitfalls will be reviewed. Attendees will learn how proper management and integrative approaches are crucial for subcutaneous naltrexone therapy to be successful.

Luis Martínez, M.D., MPH
President, XanoGene Clinic, San Juan, Puerto Rico, President, Regenera Global, Ponce, Puerto Rico





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