Feature Article: March 2020 – Age Management Medicine and Applied Healthspan Engineering: Closely Connected

Age Management Medicine and Applied Healthspan Engineering: Closely Connected

Isabela M. B. David, M.D.

All Age Management Medicine practitioners should read carefully James Larrick and Andrew Mendelsohn’s article entitled Applied Healthspan Engineering(1). The best way to explain briefly what AHE is all about is to include here the abstract of the referred article, published in 2010.

“All organisms have a minimal level of functional reserve required to sustain life that eventually declines to a point incompatible with survival at death. AHE seeks to maintain or restore optimal functional reserve of critical tissues and organs. Tissue reserve correlates with well being. Diet, physical exercise, and currently available small molecule based therapeutics may attenuate the rate of decline of specific organs or organ systems, but are unlikely to restore lost reserve. Inherent evolutionary-derived limitations in tissue homeostasis and cell maintenance necessitate the development of therapies to enhance regenerative processes and possibly replace whole organs or tissues. AHE supports the study of cell, tissue, and organ homeostatic mechanisms to derive new regenerative and tissue replacement therapies to extend the period of human health.”

When you read “AHE seeks to maintain or restore optimal functional reserve of critical tissues and organs,” you must have made a connection with Age Management Medicine, as it also aims at health optimization and maintenance. In other words, they both want to help us live better and longer.

Age Management Medicine and Applied Healthspan Engineering have developed themselves because, in the 21st century, we realised that we already have knowledge and technology to maintain health all our lives. We don’t mean that it is easy and that it is likely to happen to everyone or to most of us – at least for the moment – but it is certainly already possible to delay the rate of decline that has always being associated with ageing. For that, we must dedicate ourselves to health optimization and make use of effective tools: diet, exercise, sleep, stress management, toxin reduction, social connections and, surprising though it might sound, simplicity(2).

Figure 1, taken from Larrick and Mendelsohn’s article, shows clearly that the human healthspan begins at conception and continues until death. The first two decades of life are characterized by growth and development. Maximum vitality is obtained in the late teens and twenties, followed by gradual degeneration, accumulating morbidity and eventually death(1).

Figure 1: The Healthspan Curve
(see Figure 1)
FIG. 1. Minimal goal of Applied Healthspan Engineering (AHE) is to square the healthspan curve. Well-being peaks at the end of growth phase and then declines. AHE seeks to stabilize well-being, possibly resulting in increased longevity(1).

Considering that accumulation of molecular damage at least partially explains the process of ageing(3, 4), Age Management Medicine would also be able to contribute to squaring the healthspan curve, as proposed by AHE. In this case, the control of inflammation, oxidation and glycation biomarkers – among others, such as acidification and submethylation ones – should start at “early” age, before the maximum vitality in the late teens and twenties. The idea is to keep them optimal, not only at normal ranges.

Also, both Age Medicine Medicine and Applied Healthspan Engineering accept that one may start working on optimising his/her health at any point of the lifespan curve if the decline has already started.

The main difference between them is that Age Medicine Medicine instructs their practitioners to extend all the available knowledge and treatments directly on to the patients, while AHE is basically related to researchers who work hard on developing new regenerative and tissue replacement therapies “to extend the period of human health(1).

Last but not least, for all this, we call the 21st century Preventive Medicine the science of maintaining health.


  1. Larrick, J., & Mendelsohn, A. (2010). Applied Healthspan Engineering. Rejuvenation Research, 13, 265–280.
  2. Website: http://www.healthoptimizationprogram.com/.
  3. Giacomoni P. Ageing, science and the cosmetics industry. EMBO Rep 2005; 6: 45-48.
  4. Sergiev, P. V., Dontsova, O. A., & Berezkin, G. V. (2015). Theories of ageing: an ever-evolving field. Acta naturae, 7(1), 9–18.

Isabela M. B. David, M.D.
Clinical Nutrition Practitioner
Post-Graduate Program in Health Sciences, Universidade do Sul de Santa Catarina. Av. Pedra Branca, 25. Palhoça SC, 88137-270, Brazil. (2017)
Contact: contato.isabeladavid@gmail.com
Site: doutoraisabela.com
Instagram: @doutoraisabela