Fitness in Medicine: January 2020

Could a Pill Replace Exercise? Scientists Discover Protein Mimics Effects of Working Out

John Anderer

Ann Arbor, MI – January 13, 2020 (StudyFinds.org)Given the option, would you avoid the gym altogether and simply pop a pill or drink a supplement that brings about the same benefits as a workout? It sounds farfetched, but the idea of lounging around all day yet still enjoying the health benefits of an intense workout may soon be possible. While there are still many details to be worked out, researchers at the University of Michigan say that the naturally occurring protein Sestrin appears to mimic the effects of exercise on both flies and mice in experimental trials.

Researchers have previously observed that Sestrin accumulates in muscle following exercise,” explains Myungjin Kim, Ph.D., a research assistant professor in the Department of Molecular & Integrative Physiology, in a release.

Researchers wanted to further investigate Sestrin’s connection to exercise, so they decided to conduct an experiment using flies. They designed, in their own words, a “fly treadmill,” in which a group of flies were trained for three weeks to climb up and out of a test tube. Some of those flies were normal, while others had been specifically bred to lack the ability to make Sestrin.

“Flies can usually run around four to six hours at this point and the normal flies’ abilities improved over that period,” says professor Jun Hee Lee, Ph.D. “The flies without Sestrin did not improve with exercise.”

Also, when researchers provided another group of normal, un-trained flies with a max dose of Sestrin, these flies immediately became more adept at the treadmill, and overall physically superior to other flies, even the flies that had just spent three weeks training. Perhaps even more noteworthy, the flies given a max dosage of Sestrin didn’t appear to get in any better shape after exercising, indicating that the Sestrin alone effectively caused them to reach their full physical potential.

Besides these findings involving flies, researchers also bred a group of mice that were unable to produce Sestrin. Normally, after exercising mice should see their respiration, fat burning, and aerobic capacity improve, but this group of mice saw no such improvements after exercising.

“We propose that Sestrin can coordinate these biological activities by turning on or off different metabolic pathways,” Lee explains. “This kind of combined effect is important for producing exercise’s effects.”

Another portion of the study also found that muscle-specific Sestrin is capable of preventing atrophy in immobilized muscle groups. This often occurs whenever a limb is placed in a cast for months on end.

While all of these findings are quite remarkable, the study’s authors caution that a great deal of work remains before Sestrin is seen on nutrition store shelves. As such, don’t expect any Sestrin supplements anytime soon.

“Sestrins are not small molecules, but we are working to find small molecule modulators of Sestrin,” Lee says.

The research team say one of their top priorities moving forward is identifying how exactly exercise produces Sestrin in the body.

“This is very critical for future study and could lead to a treatment for people who cannot exercise,” Kim concludes.

The study is published in Nature Communications.

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